1. Exosomes are involved in the intercellular transfer of rapamycin resistance in the breast cancer cells

Yuri Yu. Shchegolev , Danila V. Sorokin, Alexander M. Scherbakov* , Olga E. Andreeva , Diana I. Salnikova , Ekaterina I. Mikhaevich , Margarita V. Gudkova , Mikhail A. Krasil’nikov

Bioimpacts. 2023;13(4): 313-321. doi: 10.34172/bi.2023.27490

PMCID: PMC10460766 PMID: 37645026 Scopus ID: 85168127787

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Prolonged cell treatment with mTOR inhibitor rapamycin leads to the development of resistance. Exosomes of resistant cells induce the resistance to rapamycin in the parent MCF-7cells. Exosome-induced resistance reproduces the changes revealed in the rapamycin-resistant cells, including the activation of ERK/AP-1.

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